Life Extension and Insilico Medicine using artificial intelligence to promote longevity.
Life Extension® has partnered with Insilico Medicine to identify specific nutrient combinations that function as geroprotectors. The objective is to develop innovative ways to support healthy aging.
Life Extension will introduce Ageless Cell™, the first supplement in its breakthrough GEROPROTECT™ line. Ageless Cell delivers unique ingredients which inhibit cellular senescence, a natural part of the aging process where cells no longer function optimally.
“By rejuvenating near-senescent cells and encouraging the body’s healthy process for dealing with senescent cells, Ageless Cell turns back the clock at the cellular level,” said Michael A. Smith, M.D., senior health scientist for Life Extension.
This scientific collaboration has resulted in the identification of a geroprotector formulation consisting of four nutrients with various complementary and reinforcing properties. “Clinical aging studies are extremely difficult, if not impossible, to perform at this time. Our collaboration with Insilico Medicine has allowed us to develop geroprotective formulations by using artificial intelligence to study very large data sets,” said Andrew G. Swick, Ph.D., senior vice president of product development and scientific affairs for Life Extension.
Scientists from Life Extension and Insilico Medicine worked together to identify a subset of four specific nutrients — myricetin, NAC, gamma tocotrienol, and EGCG — all of which modify senescence-inducing pathways, inhibiting the development of senescent cells.
The scientists found that the four nutrients work together, but in very different ways, to beneficially influence key anti-aging pathways. Together, they combat numerous aging factors throughout the body. These compounds all modulate specific biological pathways responsible for keeping us young and healthy.
“Combined, these ingredients promote anti-aging mechanisms at the cellular level throughout the body, acting by multiple pathways, some unique, and some overlapping,” said Alex Zhavoronkov, Ph.D., CEO of Insilico Medicine. “Together, these four natural compounds represent the beginning of the future — anti-aging cocktails identified using artificial intelligence under expert human supervision,” adds Zhavoronkov.
Modern science has uncovered a variety of natural substances capable of extending healthy life span, and these agents have been called geroprotectors.