Leading luxury aesthetic distributor Harpar Grace share the results of the latest clinical study from leading US cosmeceutical brand iS Clinical.

The study evaluated the benefits of the Active Peel System in improving dermal thickness/density and visual appearance of the skin, including fine lines & wrinkles, laxity/sagging, periorbital darkness, overall brightness, texture, pore size, radiance, luminosity, tone, and smoothness. In addition to this, the perception of participants regarding the use of the product was also evaluated.

Thirty female subjects, between 37 and 64 years of age and of various ethnic backgrounds, participated in this study. Subjects were instructed to cleanse their face and use the two-step Active Peel System, according to application instructions, every other evening on clean skin for a period of eight weeks. The same cleanser (iS Clinical Cleansing Complex) and sunscreen (iS Clinical Eclipse SPF 50+) were used throughout the study.

Visia photographs were taken of each subject at intervals throughout the study and Dermal ultrasounds were performed on all subjects and then statistically analysed to evaluate skin density/thickness.1 These measurements correlate to collagen content and there is a direct relationship between dermal thickness and collagen.2 Collagen content and dermal thickness decrease with age3 and are more robust in younger and/or less photoaged individuals. 

Higher values for skin density/thickness correlate to higher collagen content and younger age.5,6,7 This indicates a more youthful appearance, better skin recovery, resilience against traction stress (as with gravity), and delayed onset of the visual appearance of ageing. 

“We have introduced the iS Clinical Active Peel System as part of at-home skincare regimes and our patients have been delighted with the results. It also provides them with a home-use two step system to optimise the effects in between any iS Clinical professional treatment plan.”

Dr Claudia Morley MBBS MBCAM

“This is a great home-use product for skin rejuvenation and radiance, particularly for people with skin of colour. It’s suitable for both men and women and can also be used to complement other treatments such as low-level light therapy with the DÉESSE LED Mask.”

Dr Manav Bawa MBCAM

Subject responses


  • African American: 7
  • Asian: 1
  • Caucasian: 13
  • Latinx: 8
  • Native American: 1

Subject Ethnic Backgrounds

No response differences were detected among ethnic backgrounds. Overall results remained consistent among these groups with favorable responses to Active Peel System.

Subject Questionnaires

The subjects had very favourable responses to using Active Peel System, as shown below. Furthermore, as noted below, many improvements occurred very quickly. Only strongly affirmative and very strongly affirmative responses are included.


  • 70% This product reduced my oily skin or large pore size.
  • 77% I would like to continue using this product.
  • 83% My skin smoothness improved with use.
  • 93% I experienced no flaking or peeling with use.


  • 70% My skin looks better than before use.


  • 73% My skin is more radiant than before use.
  • 77% My skin seems healthier since using this product.
  • 79% This product helped unwanted pigment/pigmentary irregularities.
  • 80% My skin feels better than before use.
  • 80% My skin has a better or healthier color than before use.
  • 80% My skin texture improved with use.


1. Firooz A, Rajabi-Estarabadi A, Zartab H, Pazhohi N, Fanian F, Janani L. The influence of gender and age on the thickness and echodensity of skin. Skin Res Technol. 2017 Feb. 23(1): 13-20.

2. Shuster S, Black MM, McVitie E. The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol. 1975 Dec. 93(6): 639-64.

3. Marcos-Garces V, Aguilar PM, Serrano CB, Bustos VG, Segui JB, Izquierdo AF, Ruiz-Sauri A. Age-related dermal collagen changes during development, maturation, and ageing – a morphometric and comparative study. J Anat. 2014. 225: 98-108.

4. Frey WH. The nation is diversifying even faster than predicted, according to new census data. www.brookings.edu. 2020 Jul 1.

5. Firooz A. Op cit. 

6. Shuster S. Op cit. 

7. Marcos-Garces V. Op cit.