A recent study published in the Journal of Drugs in Dermatology has demonstrated that NeoStrata® Skin Active Line Lift helps restore volume in the skin’s matrix and improves skin elasticity, making it an effective topical treatment for reducing the appearance of deep lines and wrinkles(1).

The vehicle controlled, double-blind randomised study, comprising 70 women, was led by Patricia Farris MD, a leading dermatologist based in Los Angeles and a member of the American Academy of Dermatology (AAD).

NeoStrata® Skin Active Line Lift is a two-step topical line filler containing a new amino acid, N-Acetyl tyrosinamide, for use on targeted lines and wrinkles. The study examined the tolerability and efficacy of the topical wrinkle treatment for 16 weeks in women, aged 40–65 year, with moderate facial photodamage in target wrinkle areas (score 4–6 on a 0–9 scale).

Subjects were evaluated at weeks 0, 4, 8, 12, and 16. At each visit, a trained clinician graded glabellar lines, nasolabial folds, under eye wrinkles, and crow’s feet using a modified Griffiths’ scale (GS) from 0 (none) to 9 (severe); graded nasolabial folds using a modified Wrinkle Severity Rating Scale (WSRS); conducted timed pinch recoil measurements to assess elasticity/firmness; and evaluated skin irritation. Subjects’ faces were photographed, and subjects completed self-assessment questionnaires.

Seventy women (47 treated group, 23 vehicle group) completed the study. The two-step topical treatment was statistically superior (P<0.05) to its vehicle in improving nasolabial folds (on the WSRS), in improving glabellar lines, crow’s feet and under eye wrinkles on the GS, and in reducing pinch recoil time. Clinical photography and self-assessment scores confirmed improvement to targeted wrinkle areas.

The study authors acknowledged that some patients are reluctant to undergo injectable treatments and would benefit from a topical treatment alternative. The study concluded that NeoStrata Skin Active Line Lift was well-tolerated and effective for improving the appearance of deep expression lines in women with photodamage when used as a stand-alone treatment.

Furthermore, it could be considered as a topical adjunct to injectable therapies in difficult to treat lines, for example, in the perioral and periorbital areas, and in combination with neurotoxins, which arrest dynamic wrinkles but do not provide skin volumising effects.