SkinCeuticals Retinol 0.5 and Retinol 1.0 are now available with new improved formulations to ensure maximum efficacy and stability to enhance skin appearance and promote good skin health. SkinCeuticals Retinol 0.5 and Retinol 1.0 help diminish the appearance of fine lines, wrinkles and age spots caused by both intrinsic and photo-ageing.

Additionally they reduce the appearance of pore size and correct blemishes associated with problematic skin. The new improved lightweight formulas, containing botanical actives, lessen inflammation commonly associated with the use of some retinols.

The unique delivery system for Retinol 0.5 and Retinol 1.0 is based on the skin’s natural lipid structure and ensures delivery of high concentrations of retinol to the target site whilst the time-release technology preserves the efficacy of retinol by slow and even release to minimise erythema.

The Complete Retinol range

  • Retinol 0.3 is less concentrated and perfect for introducing retinol to patients for the first time.
  • Retinol 0.5 contains 0.5% pure retinol and is the pre-requisite to Retinol 1.0. Retinol 0.5 is suitable for patients who are looking for optimum skin quality and health maintenance.
  • Retinol 1.0 contains 1% pure retinol and is the highest concentration currently available from SkinCeuticals. It is ideal for treating photodamaged and problematic skin and should be used as an advanced treatment on patients whom have already pre-conditioned their skin with a lower level retinol and are now looking for maximum results.

Speaking at the recent ACE Conference, Dr Uliana Gout, renowned Cosmetic Physician and Founder of London Aesthetic Medicine Clinic & Academy  (co-author of The Illustrated Guide to Chemical Peeld, 2014 Quintessence) stated that “Retinols can help to stimulate cellullar turnover and collagen production; they are great wrinkle treatments. Suitable for use on face and body, retinols can form an essential component of pre and post procedural at-home advanced skincare to ensure optimum in-clinic treatment results and ongoing skin health benefits. I encourage my patients to include retinoids in my pre and post-peel skincare regimens.”  

Recommendations and usage

Retinol 0.3, 0.5 and Retinol 1.0 should be introduced in gradual steps, from initial use once or twice a week, working up to every other night and finally each evening as tolerated. Apply a pea sized amount carefully avoiding the eyes. A light moisturiser, such as SkinCeuticals Daily Moisture, can be applied after 30 minutes if wished.

Clinical Information

A recent study1 indicates that Triple Lipid Restore 2:4:2 is effective in improving the tolerance of topical retinoid treatments allowing daily use of retinol to be introduced after a shorter time period, reducing the pre-conditioning period by up to 1 week. Triple Lipid Restore 2:4:2 and a comparative lotion were applied to the face in a split-face, randomized manner. Subjects were instructed to apply topical 0.025% tretinoin (Rouses Point Pharmaceuticals) to their whole face at home every other evening for 1 week. Based on the subjects’ tolerability, topical 0.025% tretinoin application was increased to every evening at the week 1 or week 2 visit. The support regimen was limited to a basic cleanser and sunscreen.


Triple Lipid Restore 2:4:2 allowed for all 17 subjects to achieve a 1 week decrease in 0.025% tretinoin pre-conditioning. In addition, a significant improvement in dryness was observed with Triple Lipid Restore 2:4:2 at week 2, compared to baseline. At week 4, the subjects reported that the half of the face treated with Triple Lipid Restore 2:4:2 was significantly more comfortable than the half of the face treated with the comparative lotion.

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“Our mission at SkinCeuticals is to improve skin health and fight against the major causes of skin ageing. Dedicated to this purpose, we make one simple promise: to provide advanced  products, backed by science.”